Mayo Collaborators: Todd J. Schwedt, M.D, Catherine D. Chong, Ph.D

The International Classification of Headache Disorders provides criteria for the diagnosis and subclassification of migraine. Since there is no objective gold-standard by which to test these diagnostic criteria, the criteria are based on the consensus opinion of content experts. Accurate migraine classifiers consisting of brain structural measures could serve as an objective gold-standard by which to test and revise diagnostic criteria. The objectives of this study were to utilize magnetic resonance imaging measures of brain structure for constructing classifiers: 1) that accurately identify individuals as having chronic or episodic migraine vs. being a healthy control; and 2) that test the currently used threshold of 15 headache days/month for differentiating chronic migraine from episodic migraine.


  1. Schwedt, T., Chong, C., Wu, T., Gaw N., Fu, Y., Li, J., “Accurate Classification of Chronic Migraine via Brain Magnetic Resonance Imaging”, Headache.(2015 Harold G. Wolff Lecture Award Winner)
  2. Chong, C., *Gaw, N., *Fu, Y., Li, J., Wu, T., Schwedt, TJ., “Migraine classification using magnetic resonance imaging resting-state functional connectivity data”, Cephalagia, June 15, 2016, pii: 0333102416652091 (2016 Harold Wolff-John Graham Award Paper)